§01 — The knowledge base

Methylation → drug-response, as structured claims.

Each row is an evidence-graded association between a methylation locus and a drug response. This is a prototype surface over a seed corpus — the shape is real even where the rows are illustrative.

MGMT promoter methylation → temozolomide response Hypermethylation predicts response. Clinically deployed (glioblastoma).

GRADE 1A

Methylation signature → cytotoxic sensitivity (pan-cell-line) 987 GDSC lines / 8 drugs, methylation-only model, AUROC ≤ 0.97.

GRADE 2B

FDA vs CPIC dosing — shared drug set Authorities concordant on only 5 of 39 overlapping drugs.

CONTRADICTS

Whole-blood methylation clock → drug clearance (candidate) Proposed association awaiting verification against held-out cohort.

PENDING

4 of ~100 seed claims shown · full corpus + filters in build

§02 — The claim shape

Every association is a formal, provenance-stamped claim.

Not a sentence — a structured object. That's what makes it cite-able, diffable, and auditable, and what lets an agent reason over it.

claim · methylation/pgx verdict: LICENSED

subjectgenomic_region · MGMT promoter · chr10:129,466,683–129,467,448 (hg38)

predicatepredicts-response-to

objecttemozolomide

directionhypermethylation → favorable response

evidencePharmGKB 1A LICENSED

provenanceHegi/Stupp lineage · data_version 2026.06 · content-hash 0x9f3c…a12

depends_oncpg_island:MGMT · assay:EPIC_v2

§03 — The interface

Query it. Built for humans and for agents.

Ask for an association by locus, drug, or grade and get a structured answer with receipts — every response carries its evidence class, provenance, and version. The same anti-hallucination contract that powers Polymer Genomics.

# request — what does the methylome say about temozolomide? GET /v1/associations?drug=temozolomide&source=methylation # response { "association": { "subject": "MGMT_promoter", "predicate": "predicts-response-to", "object": "temozolomide", "direction": "hypermethylation_favorable", "grade": "PharmGKB-1A", "verdict": "LICENSED" }, "evidence_class": "K", // curated "contradicts": [], "provenance": { "data_version": "2026.06", "content_hash": "0x9f3c…a12" }, "confidence": 0.94 }

Whether MethylGKB ends as a hosted API, an SDK, or the assay-plus-report behind a whole-blood test is still open — the structured claim is the durable core, and every surface is a way to deliver it.

See the evidence → Back to overview