/* ──────────────────────────────────────────────────────────────────
   MethylGKB — by Polymer Genomics
   Aesthetic ported verbatim from polymerbio.org (D2: IBM Carbon ×
   Bloomberg Reference). Light-gray canvas, electric blue, hairline
   rules, Inter + JetBrains Mono, 2px radii, mono §-markers.
   Tokens mirror viewer/src/config/theme.ts + globals.css exactly.
   ────────────────────────────────────────────────────────────────── */

:root {
  /* Foundation — D2 light mode (verbatim) */
  --bg-primary:  #F4F4F5;
  --bg-elevated: #FAFAFA;
  --bg-deep:     #EBEBED;
  --bg-white:    #FFFFFF;

  --border-subtle:  #D4D4D8;
  --border-default: #E4E4E7;
  --border-strong:  #A1A1AA;

  --text-primary:   #18181B;
  --text-secondary: #3F3F46;
  --text-tertiary:  #52525B;
  --text-muted:     #71717A;
  --text-faint:     #A1A1AA;

  --primary:        #0F62FE;   /* IBM Carbon Blue 60 — the signature */
  --primary-hover:  #0043CE;
  --primary-active: #002D9C;

  /* Data-encoding colors (verbatim from viewer) — the methylation beta scale */
  --cpg-teal:        #08A097;  /* COLOR.layer.cpg_sites — unmethylated, β≈0 */
  --methyl-rose:     #BE123C;  /* COLOR.layer.methylation_atlas — methylated, β≈1 */
  --accent-amber:    #B45309;
  --accent-violet:   #7C3AED;

  --font-sans: var(--font-inter), -apple-system, BlinkMacSystemFont, 'SF Pro Text',
    'Segoe UI', Roboto, Helvetica, Arial, sans-serif;
  --font-mono: 'JetBrains Mono', 'SF Mono', 'Fira Code', monospace;

  --maxw: 1200px;
  --header-h: 56px;
}

/* next/font isn't here; load the same families from Google Fonts (see <link> in HTML).
   Expose the variable name the token stack expects. */
:root { --font-inter: 'Inter'; }

* { box-sizing: border-box; }

html, body {
  margin: 0;
  background-color: var(--bg-primary);
  color: var(--text-primary);
  font-family: var(--font-sans);
  font-feature-settings: 'cv02', 'cv03', 'cv04', 'cv11';
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  text-rendering: optimizeLegibility;
  line-height: 1.6;
}
body { min-height: 100vh; }

a { color: inherit; }

::selection { background-color: rgba(15, 98, 254, 0.18); color: var(--text-primary); }

*:focus-visible { outline: 2px solid var(--primary); outline-offset: 2px; }
*:focus:not(:focus-visible) { outline: none; }

::-webkit-scrollbar { width: 6px; height: 6px; }
::-webkit-scrollbar-track { background: var(--bg-primary); }
::-webkit-scrollbar-thumb { background: var(--border-default); }
::-webkit-scrollbar-thumb:hover { background: var(--border-strong); }

.mono { font-family: var(--font-mono); }
.tabular { font-variant-numeric: tabular-nums; }

/* ── Section marker — §01 — INTRODUCTION ──────────────────────────── */
.section-marker {
  font-family: var(--font-mono);
  font-size: 12px;
  font-weight: 500;
  letter-spacing: 0.08em;
  text-transform: uppercase;
  color: var(--text-tertiary);
  margin: 0 0 20px;
}

/* ── Layout shell ─────────────────────────────────────────────────── */
.wrap { max-width: var(--maxw); margin: 0 auto; padding: 0 24px; }
.section { padding: 88px 0; border-top: 1px solid var(--border-subtle); }
.section:first-of-type { border-top: none; }

/* ── Header ───────────────────────────────────────────────────────── */
.site-head {
  height: var(--header-h);
  display: flex;
  align-items: center;
  padding: 0 24px;
  background-color: var(--bg-primary);
  border-bottom: 1px solid var(--border-subtle);
  position: sticky;
  top: 0;
  z-index: 100;
}
.brand {
  color: var(--primary);
  font-family: var(--font-mono);
  font-size: 15px;
  font-weight: 700;
  letter-spacing: 0.12em;
  text-decoration: none;
  white-space: nowrap;
  flex-shrink: 0;
}
.brand-divider {
  width: 1px; height: 20px;
  background-color: var(--border-strong);
  margin: 0 16px;
  flex-shrink: 0;
}
.brand-sub {
  color: var(--text-tertiary);
  font-size: 14px;
  letter-spacing: 0.01em;
  white-space: nowrap;
}
.site-nav {
  margin-left: auto;
  display: flex;
  align-items: center;
  gap: 20px;
}
.nav-link {
  color: var(--text-secondary);
  font-size: 12px;
  font-weight: 500;
  letter-spacing: 0.01em;
  text-decoration: none;
  white-space: nowrap;
  transition: color 0.15s;
}
.nav-link:hover, .nav-link.is-active { color: var(--primary); }

/* ── Buttons ──────────────────────────────────────────────────────── */
.btn {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  font-family: var(--font-sans);
  font-size: 14px;
  font-weight: 500;
  letter-spacing: 0.01em;
  text-decoration: none;
  padding: 10px 18px;
  border-radius: 2px;
  cursor: pointer;
  white-space: nowrap;
  transition: background-color 0.15s, border-color 0.15s, color 0.15s;
}
.btn-primary { background-color: var(--primary); color: var(--bg-white); border: 1px solid var(--primary); }
.btn-primary:hover { background-color: var(--primary-hover); border-color: var(--primary-hover); }
.btn-secondary { background-color: var(--bg-elevated); color: var(--primary); border: 1px solid var(--border-strong); }
.btn-secondary:hover { border-color: var(--primary); }
.btn-sm { padding: 7px 14px; font-size: 12px; }

/* ── Hero ─────────────────────────────────────────────────────────── */
.hero { padding: 96px 0 72px; }
.hero h1 {
  font-size: clamp(40px, 6vw, 64px);
  line-height: 1.05;
  letter-spacing: -0.035em;
  font-weight: 600;
  margin: 0 0 28px;
  max-width: 18ch;
}
.hero h1 .em { color: var(--primary); }
.hero .lede {
  font-size: 19px;
  line-height: 1.55;
  letter-spacing: -0.01em;
  color: var(--text-secondary);
  max-width: 60ch;
  margin: 0 0 36px;
}
.hero-actions { display: flex; gap: 12px; flex-wrap: wrap; }

/* ── Beta strip (the methylation track motif) ─────────────────────── */
.beta-strip {
  margin-top: 56px;
  border: 1px solid var(--border-subtle);
  border-radius: 2px;
  background: var(--bg-elevated);
  padding: 22px 24px 18px;
}
.beta-strip-head {
  display: flex; justify-content: space-between; align-items: baseline;
  margin-bottom: 18px;
}
.beta-strip-title {
  font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--text-tertiary);
}
.beta-track {
  display: flex; align-items: flex-end; gap: 0;
  height: 60px; position: relative;
}
.cpg {
  flex: 1 1 0;
  display: flex; flex-direction: column; align-items: center; justify-content: flex-end;
  height: 100%;
}
.cpg .stem { width: 1px; background: var(--border-strong); flex: 1 1 auto; }
.cpg .dot {
  width: 11px; height: 11px; border-radius: 50%;
  border: 1.5px solid var(--cpg-teal);
  background: var(--bg-elevated);
  transform: scale(0);
  animation: cpgpop 0.5s cubic-bezier(.2,.8,.2,1) forwards;
}
@keyframes cpgpop { to { transform: scale(1); } }
.beta-scale {
  margin-top: 16px; height: 6px; border-radius: 2px;
  background: linear-gradient(90deg, var(--cpg-teal), var(--accent-amber), var(--methyl-rose));
}
.beta-scale-labels {
  display: flex; justify-content: space-between; margin-top: 6px;
  font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.04em;
  color: var(--text-muted);
}

/* ── Metrics row (Bloomberg reference) ────────────────────────────── */
.metrics {
  display: grid; grid-template-columns: repeat(3, 1fr);
  border: 1px solid var(--border-subtle); border-radius: 2px;
  background: var(--bg-elevated);
  overflow: hidden;
}
.metric { padding: 28px 26px; border-left: 1px solid var(--border-subtle); }
.metric:first-child { border-left: none; }
.metric .val {
  font-size: 44px; line-height: 1.05; letter-spacing: -0.03em; font-weight: 600;
  font-variant-numeric: tabular-nums;
}
.metric .val.teal { color: var(--cpg-teal); }
.metric .val.rose { color: var(--methyl-rose); }
.metric .val.blue { color: var(--primary); }
.metric .label {
  margin-top: 12px; font-size: 13px; line-height: 1.5; color: var(--text-secondary);
}
.metric .src {
  margin-top: 8px; font-family: var(--font-mono); font-size: 10px;
  letter-spacing: 0.04em; color: var(--text-muted); text-transform: uppercase;
}

/* ── Eyebrow + heading blocks ─────────────────────────────────────── */
.h2 { font-size: 30px; line-height: 1.2; letter-spacing: -0.025em; font-weight: 600; margin: 0 0 18px; max-width: 26ch; }
.h3 { font-size: 17px; line-height: 1.4; letter-spacing: -0.01em; font-weight: 600; margin: 0 0 8px; }
.lead { font-size: 17px; line-height: 1.6; color: var(--text-secondary); max-width: 64ch; }
.muted { color: var(--text-muted); }
.body { font-size: 14px; line-height: 1.65; color: var(--text-secondary); max-width: 70ch; }
.body p { margin: 0 0 16px; }

/* ── Cards grid ───────────────────────────────────────────────────── */
.cards { display: grid; grid-template-columns: repeat(3, 1fr); gap: 16px; margin-top: 40px; }
.card {
  background: var(--bg-elevated);
  border: 1px solid var(--border-subtle);
  border-radius: 2px;
  padding: 24px;
  text-decoration: none;
  display: flex; flex-direction: column;
  transition: border-color 0.18s, transform 0.18s;
}
a.card:hover { border-color: var(--primary); transform: translateY(-2px); }
.card .kicker {
  font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--text-tertiary); margin-bottom: 14px;
}
.card p { font-size: 14px; line-height: 1.6; color: var(--text-secondary); margin: 0; }
.card .go {
  margin-top: 18px; font-size: 13px; font-weight: 500; color: var(--primary);
}

/* ── Two-column compare (problem) ─────────────────────────────────── */
.compare { display: grid; grid-template-columns: 1fr 1fr; gap: 16px; margin-top: 40px; }
.panel {
  border: 1px solid var(--border-subtle); border-radius: 2px;
  background: var(--bg-elevated); padding: 28px;
}
.panel.muted-panel { background: var(--bg-deep); }
.panel .tag {
  font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.08em;
  text-transform: uppercase; margin-bottom: 14px;
}
.tag.dim { color: var(--text-muted); }
.tag.live { color: var(--primary); }

/* ── Module rows (hairline-divided list, hover indent) ────────────── */
.rows { border: 1px solid var(--border-subtle); border-radius: 2px; overflow: hidden; background: var(--bg-elevated); margin-top: 32px; }
.row {
  display: grid; grid-template-columns: 1fr auto; align-items: center; gap: 16px;
  padding: 18px 22px;
  border-top: 1px solid var(--border-subtle);
  text-decoration: none; color: inherit;
  transition: padding-left 0.18s ease, background-color 0.18s ease;
}
.row:first-child { border-top: none; }
.row:hover { padding-left: 30px; background-color: rgba(15, 98, 254, 0.04); }
.row .row-main { display: flex; flex-direction: column; gap: 4px; }
.row .row-name { font-size: 15px; font-weight: 500; color: var(--text-primary); }
.row .row-desc { font-size: 13px; color: var(--text-tertiary); }
.row .row-meta { font-family: var(--font-mono); font-size: 12px; color: var(--text-muted); letter-spacing: 0.02em; }
.row .row-arrow { color: var(--text-faint); transition: color 0.18s, transform 0.18s; }
.row:hover .row-arrow { color: var(--primary); transform: translateX(4px); }

/* ── Claim card (the data shape) ──────────────────────────────────── */
.claim {
  border: 1px solid var(--border-subtle); border-radius: 2px; background: var(--bg-white);
  font-family: var(--font-mono); font-size: 13px; overflow: hidden;
}
.claim-head {
  background: var(--bg-deep); padding: 12px 18px; border-bottom: 1px solid var(--border-subtle);
  font-size: 11px; letter-spacing: 0.08em; text-transform: uppercase; color: var(--text-tertiary);
  display: flex; justify-content: space-between;
}
.claim-body { padding: 18px; display: grid; gap: 12px; }
.kv { display: grid; grid-template-columns: 140px 1fr; gap: 14px; align-items: baseline; }
.kv .k { color: var(--text-muted); text-transform: uppercase; font-size: 11px; letter-spacing: 0.06em; }
.kv .v { color: var(--text-primary); }
.kv .v .hl { color: var(--primary); }

/* ── Badges ───────────────────────────────────────────────────────── */
.badge {
  display: inline-flex; align-items: center; gap: 6px;
  font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.04em;
  padding: 3px 9px; border-radius: 2px; border: 1px solid;
}
.badge.licensed { color: #15803D; border-color: #15803D; background: rgba(21,128,61,0.06); }
.badge.contradict { color: var(--methyl-rose); border-color: var(--methyl-rose); background: rgba(190,18,60,0.06); }
.badge.grade { color: var(--primary); border-color: var(--primary); background: rgba(15,98,254,0.06); }

/* ── Code block ───────────────────────────────────────────────────── */
.code {
  border: 1px solid var(--border-subtle); border-radius: 2px;
  background: #1A1A1F; color: #E4E4E7;
  font-family: var(--font-mono); font-size: 13px; line-height: 1.7;
  padding: 20px 22px; overflow-x: auto; margin-top: 24px;
}
.code .cmt { color: #71717A; }
.code .key { color: #6CB2FF; }
.code .str { color: #5FD0B0; }
.code .num { color: #E8A35C; }

/* ── References ───────────────────────────────────────────────────── */
.refs { margin-top: 28px; display: grid; gap: 0; border-top: 1px solid var(--border-subtle); }
.ref {
  display: grid; grid-template-columns: auto 1fr; gap: 16px;
  padding: 14px 0; border-bottom: 1px solid var(--border-subtle);
  font-size: 13px; color: var(--text-secondary); text-decoration: none;
}
.ref .n { font-family: var(--font-mono); font-size: 11px; color: var(--text-muted); }
.ref:hover .ref-title { color: var(--primary); }
.ref .ref-cite { color: var(--text-muted); }

/* ── Note / disclaimer ────────────────────────────────────────────── */
.note {
  margin-top: 32px; padding: 16px 20px;
  border: 1px solid var(--border-subtle); border-left: 3px solid var(--accent-amber);
  border-radius: 2px; background: var(--bg-elevated);
  font-size: 13px; line-height: 1.6; color: var(--text-secondary);
}
.note strong { color: var(--text-primary); }

/* ── Patient report ───────────────────────────────────────────────── */
.report-ctrl {
  margin-top: 44px;
  display: flex; align-items: center; justify-content: space-between; gap: 24px; flex-wrap: wrap;
  border: 1px solid var(--border-subtle); border-radius: 2px; background: var(--bg-elevated);
  padding: 22px 24px;
}
.rc-spec { display: grid; grid-template-columns: auto 1fr; gap: 6px 16px; align-items: baseline; }
.rc-spec .rc-k { font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.06em; text-transform: uppercase; color: var(--text-muted); }
.rc-spec .rc-v { font-size: 14px; color: var(--text-primary); }

.scan {
  margin-top: 24px; position: relative; overflow: hidden;
  border: 1px solid var(--border-subtle); border-radius: 2px; background: var(--bg-elevated);
  padding: 22px 24px 18px;
}
.scan-head { display: flex; justify-content: space-between; align-items: baseline; margin-bottom: 16px; }
.scan-sweep {
  position: absolute; top: 0; bottom: 0; width: 32%; left: -32%;
  background: linear-gradient(90deg, transparent, rgba(15,98,254,0.10), rgba(15,98,254,0.18), transparent);
  border-right: 1px solid var(--primary);
  pointer-events: none;
}
@keyframes sweep { from { left: -32%; } to { left: 100%; } }

.report-summary { margin-top: 8px; }

.rec-list { margin-top: 28px; border: 1px solid var(--border-subtle); border-radius: 2px; overflow: hidden; background: var(--bg-elevated); }
.rec { border-top: 1px solid var(--border-subtle); }
.rec:first-child { border-top: none; }
.rec-head {
  width: 100%; cursor: pointer; text-align: left;
  display: grid; grid-template-columns: 132px 1fr minmax(220px, 1.2fr) auto auto;
  align-items: center; gap: 18px;
  padding: 18px 22px; background: transparent; border: none; font: inherit; color: inherit;
  transition: background-color 0.15s;
}
.rec-head:hover { background-color: rgba(15, 98, 254, 0.04); }
.rec.is-open .rec-head { background-color: rgba(15, 98, 254, 0.04); }
.rec-call {
  justify-self: start;
  font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.04em;
  padding: 4px 10px; border-radius: 2px; border: 1px solid; white-space: nowrap;
}
.rec-call.favorable { color: #15803D; border-color: #15803D; background: rgba(21,128,61,0.06); }
.rec-call.caution   { color: var(--accent-amber); border-color: var(--accent-amber); background: rgba(180,83,9,0.06); }
.rec-call.avoid     { color: var(--methyl-rose); border-color: var(--methyl-rose); background: rgba(190,18,60,0.07); }
.rec-call.monitor   { color: var(--primary); border-color: var(--primary); background: rgba(15,98,254,0.06); }
.rec-main { display: flex; flex-direction: column; gap: 3px; min-width: 0; }
.rec-drug { font-size: 16px; font-weight: 600; color: var(--text-primary); }
.rec-cls { font-size: 12px; color: var(--text-tertiary); }
.rec-signal { display: flex; align-items: center; gap: 10px; min-width: 0; }
.readout-dot { width: 12px; height: 12px; border-radius: 50%; border: 1.5px solid; flex-shrink: 0; }
.rec-locus { font-size: 13px; color: var(--text-secondary); white-space: nowrap; overflow: hidden; text-overflow: ellipsis; }
.rec-beta { font-size: 12px; color: var(--text-muted); white-space: nowrap; }
.rec-chev { color: var(--text-faint); transition: transform 0.18s; justify-self: end; }
.rec.is-open .rec-chev { transform: rotate(180deg); color: var(--primary); }
.rec-detail { padding: 4px 22px 22px; }
.rec-note { font-size: 14px; line-height: 1.6; color: var(--text-secondary); margin: 0; max-width: 80ch; }

@media (max-width: 880px) {
  .rec-head { grid-template-columns: auto 1fr auto; gap: 12px; }
  .rec-signal, .rec-grade { grid-column: 1 / -1; }
  .rec-chev { display: none; }
  .report-ctrl { flex-direction: column; align-items: stretch; }
}
@media (prefers-reduced-motion: reduce) { .scan-sweep { display: none; } }

/* ── Footer ───────────────────────────────────────────────────────── */
.site-foot {
  background: var(--bg-primary);
  border-top: 1px solid var(--border-subtle);
  padding: 18px 24px;
  display: flex; align-items: center; justify-content: space-between; flex-wrap: wrap; gap: 14px;
  margin-top: 0;
}
.foot-links { display: flex; align-items: center; gap: 14px; flex-wrap: wrap; }
.foot-links a { color: var(--text-tertiary); font-size: 12px; text-decoration: none; letter-spacing: 0.01em; transition: color 0.15s; }
.foot-links a:hover { color: var(--primary); }
.foot-dot { color: var(--border-strong); font-size: 12px; }
.foot-meta { display: flex; align-items: center; gap: 14px; }
.ruo {
  color: var(--text-tertiary); font-family: var(--font-mono); font-size: 11px;
  letter-spacing: 0.08em; text-transform: uppercase; text-decoration: none;
  border-bottom: 1px dotted var(--text-faint);
}
.copy { color: var(--text-muted); font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.04em; }

/* ── Responsive ───────────────────────────────────────────────────── */
@media (max-width: 880px) {
  .metrics, .cards, .compare { grid-template-columns: 1fr; }
  .metric { border-left: none; border-top: 1px solid var(--border-subtle); }
  .metric:first-child { border-top: none; }
  .brand-divider, .brand-sub { display: none; }
  .site-nav { gap: 14px; }
  .kv { grid-template-columns: 1fr; gap: 4px; }
}
@media (prefers-reduced-motion: reduce) {
  .cpg .dot { animation: none; transform: scale(1); }
  a.card:hover { transform: none; }
}