/* ──────────────────────────────────────────────────────────────────
   Strata v2 — cross-indication opportunity engine.
   Additive styles only. Inherits all tokens + base from styles.css
   and transcript / agent-explainer chrome from strata.css.
   No new colors introduced outside the existing palette.
   ────────────────────────────────────────────────────────────────── */

/* ── Back-link + run control row ─────────────────────────────────── */
.v2-runctl {
  margin-top: 24px;
  display: flex; align-items: center; gap: 14px; flex-wrap: wrap;
}
.v2-back {
  font-family: var(--font-mono); font-size: 12px; letter-spacing: 0.04em;
  color: var(--text-muted); text-decoration: none;
  transition: color 0.15s;
}
.v2-back:hover { color: var(--primary); }

/* ── Transcript + post-reveal sections start hidden ──────────────── */
.v2-reveal { transition: opacity 0.4s ease; }
.v2-reveal[hidden] { display: none; }

/* ── Featured cards grid ─────────────────────────────────────────── */
.opp-cards {
  display: grid; grid-template-columns: repeat(3, 1fr); gap: 16px; margin-top: 28px;
}
.opp-card {
  border: 1px solid var(--border-subtle); border-radius: 2px;
  background: var(--bg-elevated);
  display: flex; flex-direction: column;
  overflow: hidden;
}
.opp-card-head {
  padding: 18px 20px 14px;
  border-bottom: 1px solid var(--border-subtle);
  background: var(--bg-deep);
}
.opp-card-title {
  display: flex; align-items: center; gap: 10px; flex-wrap: wrap;
  margin-bottom: 8px;
}
.opp-card-drug {
  font-size: 17px; font-weight: 600; color: var(--text-primary); letter-spacing: -0.01em;
}
.opp-card-arrow {
  color: var(--text-muted); font-size: 15px;
}
.opp-card-marker {
  font-size: 17px; font-weight: 600; color: var(--primary); letter-spacing: -0.01em;
}
.opp-level-badge {
  font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.06em;
  padding: 2px 8px; border-radius: 2px; border: 1px solid var(--primary);
  color: var(--primary); background: rgba(15,98,254,0.06);
  white-space: nowrap;
}
.opp-card-tag {
  font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.08em;
  text-transform: uppercase; padding: 3px 9px; border-radius: 2px; border: 1px solid;
  align-self: flex-start; white-space: nowrap;
}
.opp-tag-control { color: #15803D; border-color: #15803D; background: rgba(21,128,61,0.06); }
.opp-tag-novel   { color: var(--accent-violet); border-color: var(--accent-violet); background: rgba(124,58,237,0.06); }

.opp-card-pathway {
  font-family: var(--font-mono); font-size: 11px; letter-spacing: 0.04em;
  color: var(--text-muted); margin-top: 6px;
}

/* ── Stats row ────────────────────────────────────────────────────── */
.opp-stats {
  display: flex; gap: 0; border-bottom: 1px solid var(--border-subtle);
  background: var(--bg-white);
}
.opp-stat {
  flex: 1; padding: 12px 14px; border-right: 1px solid var(--border-subtle);
  display: flex; flex-direction: column; gap: 3px;
}
.opp-stat:last-child { border-right: none; }
.opp-stat-val {
  font-family: var(--font-mono); font-size: 15px; font-weight: 600;
  color: var(--text-primary); font-variant-numeric: tabular-nums; letter-spacing: -0.01em;
}
.opp-stat-val.neg { color: var(--cpg-teal); }
.opp-stat-lbl {
  font-size: 10px; letter-spacing: 0.04em; text-transform: uppercase;
  color: var(--text-muted); line-height: 1.3;
}

/* ── Tissue recurrence panel ─────────────────────────────────────── */
.opp-tissue-head {
  font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--text-tertiary);
  padding: 12px 16px 6px;
}
.opp-tissue-list {
  padding: 0 16px 12px;
  display: flex; flex-direction: column; gap: 4px;
}
.opp-tissue-row {
  display: grid; grid-template-columns: 1fr 36px auto; gap: 8px;
  align-items: center; font-size: 11px; line-height: 1.4;
}
.opp-tissue-name {
  color: var(--text-secondary); white-space: nowrap; overflow: hidden; text-overflow: ellipsis;
}
.opp-tissue-sig { color: var(--text-muted); }
.opp-tissue-sig.is-sig { color: #15803D; font-weight: 600; }
.opp-tissue-bar-wrap {
  height: 6px; position: relative;
  display: flex; align-items: center;
}
/* bars are drawn inline via JS using flex + a span */
.opp-tissue-bar {
  height: 6px; border-radius: 1px; min-width: 1px;
  transition: width 0.4s ease;
}
.opp-tissue-bar.neg-bar { background: var(--cpg-teal); }
.opp-tissue-bar.pos-bar { background: var(--accent-amber); }

/* ── Mechanism card ──────────────────────────────────────────────── */
.opp-mech {
  border-top: 1px solid var(--border-subtle);
  padding: 14px 16px; background: var(--bg-white);
  flex: 1;
}
.opp-mech-state {
  font-size: 12px; font-weight: 600; color: var(--text-primary); margin-bottom: 8px;
  line-height: 1.4;
}
.opp-mech-kv {
  display: flex; flex-direction: column; gap: 6px;
  font-size: 12px; line-height: 1.55; color: var(--text-secondary);
}
.opp-mech-k {
  font-family: var(--font-mono); font-size: 9.5px; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--text-muted); display: block; margin-bottom: 1px;
}
.opp-level-note {
  margin-top: 10px; padding: 8px 12px;
  background: var(--bg-deep); border-radius: 2px;
  font-family: var(--font-mono); font-size: 10.5px; color: var(--text-muted);
  line-height: 1.5; letter-spacing: 0.01em;
}

/* ── Replicated-by chips ─────────────────────────────────────────── */
.opp-replicated {
  border-top: 1px solid var(--border-subtle);
  padding: 10px 16px 12px;
  background: var(--bg-elevated);
}
.opp-replicated-lbl {
  font-family: var(--font-mono); font-size: 9.5px; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--text-muted); margin-bottom: 6px;
}
.opp-rep-chips { display: flex; flex-wrap: wrap; gap: 6px; }
.opp-rep-chip {
  font-family: var(--font-mono); font-size: 11px;
  border: 1px solid var(--border-subtle); border-radius: 2px;
  padding: 3px 9px; background: var(--bg-white);
  color: var(--text-secondary);
}
.opp-rep-chip strong { color: var(--text-primary); }

/* ── Negative control callout ─────────────────────────────────────── */
.neg-control {
  margin-top: 28px;
  border: 1px solid var(--border-subtle); border-left: 3px solid var(--methyl-rose);
  border-radius: 2px; background: var(--bg-elevated);
  padding: 18px 20px;
}
.neg-control-label {
  font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--methyl-rose); margin-bottom: 8px; display: block;
}
.neg-control p { margin: 0; font-size: 13px; line-height: 1.6; color: var(--text-secondary); }
.neg-control strong { color: var(--text-primary); }

/* ── Opportunity table ────────────────────────────────────────────── */
.opp-table-wrap {
  margin-top: 28px;
  border: 1px solid var(--border-subtle); border-radius: 2px; overflow: hidden;
  background: var(--bg-elevated);
}
.opp-table {
  width: 100%; border-collapse: collapse;
  font-family: var(--font-mono); font-size: 12.5px;
}
.opp-table caption {
  font-size: 11px; color: var(--text-muted); letter-spacing: 0.04em;
  padding: 10px 16px; text-align: left; caption-side: bottom;
  border-top: 1px solid var(--border-subtle);
}
.opp-table th {
  text-align: left; font-size: 10px; letter-spacing: 0.06em; text-transform: uppercase;
  color: var(--text-muted); font-weight: 500; padding: 10px 16px;
  background: var(--bg-deep); border-bottom: 1px solid var(--border-subtle);
}
.opp-table th.num, .opp-table td.num {
  text-align: right; font-variant-numeric: tabular-nums;
}
.opp-table td {
  padding: 9px 16px; border-top: 1px solid var(--border-subtle);
  color: var(--text-secondary);
}
.opp-table tbody tr:first-child td { border-top: none; }
.opp-table tbody tr:hover td { background: rgba(15,98,254,0.03); }
.opp-table .td-drug { color: var(--text-primary); font-weight: 500; }
.opp-table .td-marker { color: var(--primary); }
.opp-table td.num.neg { color: var(--cpg-teal); }
.opp-table td.num.pos { color: var(--accent-amber); }

/* ── Evidence ladder ─────────────────────────────────────────────── */
.evidence-ladder {
  display: flex; gap: 0; margin-top: 28px;
  border: 1px solid var(--border-subtle); border-radius: 2px; overflow: hidden;
}
.ev-rung {
  flex: 1; padding: 14px 14px;
  border-right: 1px solid var(--border-subtle);
  display: flex; flex-direction: column; gap: 6px;
  background: var(--bg-elevated);
  transition: background 0.15s;
}
.ev-rung:last-child { border-right: none; }
.ev-rung.is-active { background: rgba(15,98,254,0.06); }
.ev-rung-level {
  font-family: var(--font-mono); font-size: 14px; font-weight: 700;
  color: var(--text-muted); line-height: 1;
}
.ev-rung.is-active .ev-rung-level { color: var(--primary); }
.ev-rung-label { font-size: 11px; line-height: 1.4; color: var(--text-tertiary); }
.ev-ladder-cap {
  margin-top: 12px; font-family: var(--font-mono); font-size: 11px;
  color: var(--text-muted); letter-spacing: 0.04em;
}
.ev-ladder-cap strong { color: var(--primary); }

/* ── Prior art / honesty note ────────────────────────────────────── */
.honesty-note {
  margin-top: 24px;
  border: 1px solid var(--border-subtle); border-left: 3px solid var(--accent-violet);
  border-radius: 2px; background: var(--bg-elevated);
  padding: 16px 20px;
  font-size: 13px; line-height: 1.65; color: var(--text-secondary);
}
.honesty-note strong { color: var(--text-primary); }
.honesty-note .hn-label {
  font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.08em;
  text-transform: uppercase; color: var(--accent-violet);
  display: block; margin-bottom: 6px;
}

/* ── Responsive ───────────────────────────────────────────────────── */
@media (max-width: 1000px) {
  .opp-cards { grid-template-columns: 1fr; }
  .evidence-ladder { flex-direction: column; }
  .ev-rung { border-right: none; border-bottom: 1px solid var(--border-subtle); }
  .ev-rung:last-child { border-bottom: none; }
}
@media (max-width: 640px) {
  .opp-stats { flex-wrap: wrap; }
  .opp-stat { min-width: 50%; }
}
@media (prefers-reduced-motion: reduce) {
  .t-step { opacity: 1; transform: none; animation: none; }
  .t-cursor { animation: none; }
  .opp-tissue-bar { transition: none; }
}